Kerem et al. Sun, Y. Chambers, and M.
Duffaut, A. Quintero, J. Jun et al.
Increased angiogenesis [ 84 ]. Du et al.
Quintero, P. In this sense, diet has a main role in the inflammation [ 35 , 36 ] and oxidative stress-related outcomes [ 37 , 38 ].
McCann, M. Hopf, Z. Oxidative stress, altered PO 2 , and endoplasmic reticulum stress are potential triggering factors for metaflammation development. In this sense, it is interesting to note that weight reduction increases partial oxygen arterial blood pressure PaO 2 and, also, that morbidly obese women seem to have at rest a better gas exchange [ 108 ].
Figure 1: A strong correlation between Mcp-1 mRNA expression and ROS release was also found [ 46 ], a result that is in accordance with other studies showing that ROS production could increase Mcp-1 expression [ 124 ].
Interestingly, some of these favorable outcomes occur under high and low oxygen concentrations.
References M. Obesity itself is characterized by a state of mild chronic inflammation in humans [ 28 ]. Peng, S.
Bai, K. Fjeldborg, S.
Adipose tissue is constituted not only by adipocytes, but also by a stromavascular cell fraction, which involves leukocytes including macrophages , T cells, and natural killer cells [ 43 ]. Al-Waili, G. Overall, these studies evidence that oxygen exposure has also important positive effects at a systemic level, being able to ameliorate inflammation and metabolic disruptions, which are features commonly presented in obesity.