Are "shotgun cloning" and "clone based sequencing" actually mutually exclusive terms?
The v short answer is that in shotgun sequencing, the sequencer is fed a set of random sequences from the target. Celera were competing with Sanger and collaborators to sequence the human genome.
What's the difference between shotgun sequencing and clone based sequencing? Email Required, but never shown.
I think you better mean whole genome shotgun sequencing with "shotgun sequencing" as the clone based sequencing also is a shotgun sequencing method. In clone based sequencing, the DNA to be sequenced is specifically sectioned off into sequence copied into of plasmids BACs - bacterial artificial chromosome to divide the sequencing job into sections- a divide and conquer strategy.
The public project cut up the genome into BACs and shotgunned every BAC, and then put the BACs together, while Venter used some sequence position information from the public effort to help him place his shotgun pieces.