Alexander LJ 1994 Primary care of the posterior segment.
Failure to achieve or maintain emmetropia leads to the development of refractive errors, i. PLoS Genet 11 8: Nature 467: Can J Ophthalmol 32: Invest Ophthalmol Vis Sci 34: Negative values indicate a positive correlation with myopia and a negative correlation with hyperopia i.
Component dependent risk factors for ocular parameters in Singapore Chinese children. Prog Retin Eye Res. Therefore, we then analyzed the expression of Aplp2 in the retina at the mRNA and protein levels. This finding remained significant after adjusting for diopter-hours of near work and school performance.
Brain Res 124: Optom Vis Sci. The prevalence of refractive errors among adults in the United States, Western Europe, and Australia. Author Affiliations Mohamed Dirani.Genetic Testing in Ophthalmology – Focus on Eye Panels at PreventionGenetics
Therefore, it is postulated that myopia develops when the reduction of the refractive power of the cornea and lens falls short of matching the axial elongation during the early development of emmetropia. We found that Aplp2 modulated sensitivity to retinal image degradation induced by form-deprivation in a dose-dependent manner, yet, lack of Aplp2 did not cause an observable change in visual acuity.
Abstract Myopia is the most common vision disorder and the leading cause of visual impairment worldwide. Ocular refraction: Furthermore, the importance of eye growth axial elongation in the development of refractive error has been clearly demonstrated, and a large amount of data are also available to support a genetic involvement in both refraction and axial length.
Each twin underwent a general questionnaire and comprehensive eye examination, including a dilated objective refraction and axial length measurement.
S1 Text. For instance, in a recent study, Ip et al.
The reduced susceptibility to myopia in mice lacking Aplp2 makes lowering the level of APLP2 in the retina via gene therapy an appealing future direction for therapeutic intervention in human myopia.